Research

Scientific activity of the Department of Dermatovenereology

Basic scientific theme:

  • Studies of pathogenesis of chronic dermatoses, improvement of treatment methods. Prevention of sexual transmitted diseases.

Additional scientific directions:

  • Study of physiological and pathological aspects of the skin and inferior urogenital tract
  • Elucidation of some pathogenic aspects of the skin and sexually transmitted diseases
  • Mastering of some new methods for diagnostic and treatment of the skin diseases and sexually transmitted infections

Research projects which were realized in collaboration with international partners:

  • Grant project “Development of evidence-based clinical standards for STI management in Central and Eastern Europe” of IUSTI and WHO-Europe, which goal was to elaborate a National Guide for management of sexual transmitted infections. In this projects participated Dr. John Richens, Department of Sexually Transmitted Diseases, Great Britain (total financial volume were estimated at 20.000 $, quota of money which had been received by the members of department during period of 2003-2004 were 113.025 lei). Deadline for realization: June 2003-May 2005.

Research projects which were realized in collaboration with national partners:

  • Prof. Gh. Muset. Theme: “Entomological products with hepatoprotective, immunomodulatory and antiinflammatory properties”, 2007-2008, in collaboration with ASM
  • Prof. Gh. Muset. Theme: “Usage of imupurin for prophylaxis of acquired immunodeficiency states”, 2009-2010, in collaboration with ASM.

Summary of PhD thesis performed at the department:

  • V.Gogu. Psoriasis in children: clinical, hormone, immunological studies and treatment. Thesis for PhD degree was defended at Specialized Scientific Council DH-14.93.32 from 31.05.2000. The obtained results had enlarged the concept about initiating role of prolactin in evolution of psoriasis in children, which level is certainly increased in both girls and boys. Overexpression of stress hormones in children with psoriasis is associated with an exaggerated as cellular as well as humoral. Investigations which had been done in this study appreciated a benign effect of a dopaminergic medicine bromcriptin for therapy of psoriasis in children that may be used for a complex treatment of the diseases as in children as well as in adults.
  • B.Nedelciuc. Contemporary clinical and immunological aspects of acne vulgaris and improvement of treatment methods. Thesis for PhD degree was defended at Specialized Scientific Council DH-14.93.32 from 06.09.2000. Researcher realized next conclusions which were implemented in practice: in patients with acne there is an immune disbalance, especially cellular one, which becomes more evident if diseases get worse; treatment must be done in complex, taking into account bacteriologic smear, level of metabolic, immune and hormone  alterations; inclusion of immunomodulator licopid in the treatment formula for acne discover new therapeutic options; implementation of all three steps of anti-acne prophylaxis creates the opportunity for decrease of morbidity level and minimization of medication.
  • M. Betiu. Eczema: peroxide oxidation of lipids, antioxidant system and lysosomal enzymes activity; therapeutic corrections. Thesis for PhD degree was defended at Specialized Scientific Council DH-14.93.32 from 27.02.2002. The author concludes: in eczema of mixed origin (exo-endogenous) oxidative stress is manifested in patients by activation of peroxide oxidation of lipids with increasing in erythrocytes and serum the level of lipid hydroperoxides and malonate dialdehyde; biochemical alterations of erythrocytes and serum are in concordance with topographic sites of skin involvement, being more evident in disseminated forms of eczema; oxidative stress occurred in eczema is associated with inhibition of anti-oxidative system, expressed by depression of the most important anti-oxidative parameters  as well as by alterations of glutathione cycle enzymes; vulnerability of cellular membranes and increasing activity of lysosomal enzymes,which occur in eczema, are due to cellular oxidative stress, this event induces the level of topographic skin involvement through increasing of lysosomal enzymes activity in erythrocytes and plasma which is directly proportional to inflammatory surface; comparative analysis of different therapeutical schema which had been administrated to patients included in study demonstrated  a priority effect of complex therapy (delagil and vitamins E,C) on elimination of  skin manifestations of eczema and regulation of biochemical status  vice versa standard treatment.
  • Elena Raevchi. Medico-social aspects, principles of complex diagnostic and treatment of nevocellular nevus. Thesis for PhD degree was defended at Specialized Scientific Council DH-14.93.32 from 29.03.2003. A number of patients with nevocellular nevus were investigated by clinical, histological and statistical methods and maximal morbidity was demonstrated within 3 age groups: 11-15 years, 26-30years and 41-45 years. People with phototypes I and II (blue or green eyes, blond hair) have an increased risk of nevus development. At the same time, the efficacy of “Izonidez” in prevention of unaesthetic postoperative scars was shown.
  • Angela SavinGrosu. Study of antifungal action of some authentic medicines with vegetal origin, 2009.